Biography

Dr Alexa Childs is a postdoctoral clinical research fellow at the University College London and medical oncology consultant at the Royal Free Hospital specialising in HPB malignancies and clinical trials within the NIHR Clinical Research Facility. Her PhD focused on single cell Whole-Genome Sequencing of circulating tumour cells in patients with advanced Neuroendocrine tumours.

GMC number

7016830

Childs A, Zakeri N, Ma YT, O’Rourke J, Ross P, Hashem E, Hubner RA, Hockenhull K, Iwuji C, Khan S, Palmer DH, Connor J, Swinson D, Darby S, Braconi C, Roques T, Yu D, Luong TV, Meyer T. Biopsy for Advanced Hepatocellular Carcinoma – Results of a Multicentre UK Audit. Br J Cancer. 2021 Nov;125(10):1350-1355. doi: 10.1038/s41416-021-01535-2. Epub 2021 Sep 15. PMID: 34526664; PMCID: PMC8575957.

Childs A, Steele CD, Vesely C, Rizzo FM, Ensell L, Lowe H, Dhami P, Vaikkinen H, Luong TV, Conde L, Herrero J, Caplin M, Toumpanakis C, Thirlwell C, Hartley JA, Pillay N, Meyer T. Whole-genome sequencing of single circulating tumor cells from neuroendocrine neoplasms. Endocr Relat Cancer, 2021 Aug 11;28(9):631-644. doi: 10.1530/ERC-21-0179.

Vesely C, Wong YNS, Childs A, Akarca AU, Dhami P, Vaikkinen H, Conde L, Herrero J, Ogunbiyi O, Gander A, Luong TV, Thirlwell C, Caplin M, Toumpanakis C, Peggs K, Quezada SA, Marafioti T, Meyer T. Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors. Clin Cancer Res. 2022 Jun 13;28(12):2657-2668. doi: 10.1158/1078-0432.CCR-21-4203. PMID: 35320356.

Childs A, Vesely C, Ensell L, Lowe H, Luong TV, Caplin ME, Toumpanakis C, Thirlwell C, Hartley JA, Meyer T. Expression of somatostatin receptors 2 and 5 in circulating tumour cells from patients with neuroendocrine tumours.  British Journal of Cancer, 2016 Dec 6;115(12):1540-1547

Childs A, Kirkwood A, Edeline J, Luong TV, Watkins J, Lamarca A, Alrifai D, Nsiah-Sarbeng P, Gillmore R, Mayer A, Thirlwell C, Sarker D, Valle JW, Meyer T. Ki-67 Index and response to chemotherapy in patients with neuroendocrine tumours. Endocrine-Related Cancer, 2016 Jul;23(7):563-70.

Lamarca A, Walter T, Pavel M, Borbath I, Freis P, Nunez B, Childs A, Mcnamara MG, Hubner RA, Garcia-Carbonero R, Meyer T,  Valle JW, Barriuso J. Design and Validation of the GI-NEC Score to Prognosticate Overall Survival in Patients with High-grade Gastrointestinal Neuroendocrine Carcinomas. J Natl Cancer Institute. 2017 Jan 27;109(5).

Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG. Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres. World J Gastroenterol 2019; 25(39): 5991-6005 [PMID: 31660035 DOI: 10.3748/wjg.v25.i39.5991].

Rizzo FM, Vesely C, Childs A, Marafioti T, Khan MS, Mandair D, Cives M, Ensell L, Lowe H, Akarca AU, Luong T, Caplin M, Toumpanakis C, Krell D, Thirlwell C, Silvestris F, Hartley JA, Meyer T. Circulating tumour cells and their association with bone metastases in patients with neuroendocrine tumours. Br J Cancer. 2019 Feb;120(3):294-300. doi: 10.1038/s41416-018-0367-4. Epub 2019 Jan 14.PMID: 30636773 

 

  

Dr Alexa Child's research interests are in early phase clinical trials and translational research focused on immuno-biology and therapeutics.