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Job title
Consultant nephrologist and honorary associate professor
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Biography
Dr Evans studied medicine at Cambridge University and University College London Medical School, qualifying in 2007. He undertook general medical training in London and Melbourne, Australia before his specialty training in Nephrology in North Thames. He was awarded a fellowship in transplantation at the University of British Columbia, Canada, which he completed in 2021. He works as an Associate Professor of Renal Medicine and Honorary Consultant Nephrologist at the UCL Centre for Kidney and Bladder Health, Royal Free Hospital.
His practice encompasses all aspects of general nephrology including the investigation of acute and chronic kidney disease. He has sub-speciality expertise in transplantation, including donor and recipient assessment and post-transplant care, as well as in the management of patients with inherited and acquired tubular kidney diseases. He is deputy lead of the UCL Transplant theme and is principal investigator on several clinical trials.
Dr Evans received a PhD from UCL for translational work investigating the impact of salt on the immune system. He was awarded the UCL Oliver Wrong Prize for outstanding contribution to renal physiology research in 2021.
Languages
English
Selected Publications
• Evans, R.D.R., Antonelou, M., Sathiananthamoorthy, S. et al. Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses. Nat Commun 11, 4368 (2020)
• Evans, R. D. R. et al. Use and Outcomes of Induction Therapy in Well-Matched Kidney Transplant Recipients. Clin. J. Am. Soc. Nephrol. CJASN 17, 271–279 (2022).
• Evans RDR, et al. Diagnostic performance of a point-of-care saliva urea nitrogen dipstick to screen for kidney disease in low-resource settings where serum creatinine is unavailable. BMJ Glob Health. 2020 May;5(5).
• Evans RDR, et al. Emerging evidence of an effect of salt on innate and adaptive immunity. Nephrol Dial Transplant. 2019 Dec 1;34(12):2007–14.
Other Journal Publications
• Albakr, R…Evans R.D.R et al. An ISN-DOPPS survey of the global impact of the Coronavirus 2019 pandemic on peritoneal dialysis services. Kidney Int. Rep. (2022) doi:10.1016/j.ekir.2022.07.013
• Tannor, E. K. ….Evans, R.D.R…et al. The COVID-19 Pandemic Identifies Significant Global Inequities in Hemodialysis Care in Low and Lower-Middle Income Countries-An ISN/DOPPS Survey. Kidney Int. Rep. 7, 971–982 (2022)
• T.-L., Evans, R. D. R., et al. Assessment of measurement of salivary urea by ATR-FTIR spectroscopy to screen for chronic kidney disease. Kidney360 (2021) doi:10.34067/KID.0004362021.
• Aylward, R. …Evans R…et al. The global impact of the Coronavirus 2019 pandemic on in-centre haemodialysis services: an International Society of Nephrology -Dialysis Outcomes Practice Patterns Study survey. Kidney Int. Rep. 0, (2021).
• Evans, R. D. R., Smyth, B., Levin, A., Jha, V., Wheeler, D. C., Jardine, M., Perkovic, V., Damster, S., Malik, C., de Zeeuw, D., & Hiemstra, T. (2021). The International Society of Nephrology Advancing Clinical Trials (ISN-ACT) Network: Current activities and future goals. Kidney International, 99(3), 551–554. https://doi.org/10.1
• Antonelou, M., Evans, R. D. R., Henderson, S. R. & Salama, A. D. Neutrophils are key mediators in crescentic glomerulonephritis and targets for new therapeutic approaches. Nephrol. Dial. Transplant (2020) doi:10.1093/ndt/gfaa206.
• Evans RDR, Phiri C. Assessing and Improving the Capacity of District Health Services in the Management of Acute Kidney Injury in Low- and Middle-Income Countries. Kidney Int Rep. 2020 Jul;5(7):977–9.
• Selby NM, Forni LG, Laing CM, Horne KL, Evans RD, et al. Covid-19 and acute kidney injury in hospital: summary of NICE guidelines. BMJ. 2020 May 26;369:m1963.
• Yang C-W, Harris DCH, Luyckx VA, Nangaku M, Hou FF, Garcia Garcia G,.. Evans R et al. Global case studies for chronic kidney disease/end-stage kidney disease care. Kidney Int Suppl. 2020 Mar;10(1):e24–48.
• Antonelou M, Michaëlsson E, Evans RDR, et al. Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN. J Am Soc Nephrol JASN. 2020 Feb;31(2):350–64
• Hussein RH, Calice-Silva V, Evans R, et al. Diagnosis of Acute Kidney Injury in Children Hospitalized in a Sub-Saharan African Unit by Saliva Urea Nitrogen Dipstick Test. Blood Purif. 2020;49(1–2):185–96.
• Evans, R. et al. Clinical Manifestations and Long-term Outcomes of IgG4-Related Kidney and Retroperitoneal Involvement in a United Kingdom IgG4-Related Disease Cohort. Kidney Int. Rep. 0, (2018).
• Calice-Silva V, Sacomboio E, Raimann JG, Evans R, et al. Diagnostic performance of salivary urea nitrogen dipstick to detect and monitor acute kidney disease in patients with malaria. Malar J. 2018 Dec 18;17(1):477.
• Evans, R. D. et al. Incidence, etiology, and outcomes of community-acquired acute kidney injury in pediatric admissions in Malawi. Perit. Dial. Int. J. Int. Soc. Perit. Dial. (2018). doi:10.3747/pdi.2017.00253
• Evans, R. D. R. et al. Assessment of a Dedicated Transplant Low Clearance Clinic and Patient Outcomes on Dialysis After Renal Allograft Loss at 2 UK Transplant Centers. Transplant. Direct 4, e352 (2018)
• Chikwapulo, B., Ngwira, B., Sagno, J. B. & Evans, R. Renal outcomes in patients initiated on tenofovir disoproxil fumarate-based antiretroviral therapy at a community health centre in Malawi. Int. J. STD AIDS 29, 650–657 (2018).
• Cooke, W. R., Hemmila U.K, Craik, A.L, Mandala C.J, Mvula, P, Msusa, A, Dreyer, G, and Evans R. Incidence, aetiology and outcomes of obstetric-related acute kidney injury in Malawi: a prospective observational study. BMC Nephrol. 19, 25 (2018).
• Evans, R. D. R. et al. A Salivary Urea Nitrogen Dipstick to Detect Obstetric-Related Acute Kidney Disease in Malawi. Kidney Int. Rep. 3, 178–184 (2018).
• Vachharajani, T. J., Bello, A. K., Evans, R., et al. Nephrology Education and Continuing Education in Resource-Limited Settings. Semin. Nephrol. 37, 224–233 (2017).
• Evans R, et al. Diagnostic Performance of a Saliva Urea Nitrogen Dipstick to Detect Kidney Disease in Malawi. Kidney Int Rep. 2017 Mar 1;2(2):219–27.
• Evans RDR, et al. Incidence, aetiology and outcome of community-acquired Acute Kidney Injury in medical admissions in Malawi. BMC Nephrol. 18, 21 (2017).
• Craik A, Hemmila U, Mtekateka M, Kawale Z, Kalata O, Manda L, Kumwenda V, Dreyer G, Evans, RDR. Partnerships to improve the detection and management of kidney disease globally – an update on the Bart’s-Malawi programme. British Journal Renal Medicine. 2016;4(1): 107-111.
• Kirwan CJ, Wright K, Banda P, Chick A, Evans R, et al. A nurse-led intervention improves detection and management of AKI in Malawi. J Ren Care. 2016 Sep 1
• Raimann JG, Calice-Silva V, Thijssen S, Nerbass FB, Evans R, et al. Saliva Urea Nitrogen Continuously Reflects Blood Urea Nitrogen after Acute Kidney Injury Diagnosis and Management: Longitudinal Observational Data from a Collaborative, International, Prospective, Multicenter Study. Blood Purif. 2016;42(1):64–72.
• Evans RDR, et al. Tubulointerstitial nephritis in primary Sjögren syndrome: clinical manifestations and response to treatment. BMC Musculoskelet Disord. 2016;17(1):2
• Evans R, et al. Deficiencies in education and experience in the management of acute kidney injury among Malawian healthcare workers. Malawi Med J. 2015;27(3):101–3.
• Evans R, et al. Renal involvement in primary Sjögren’s syndrome. Rheumatol Oxf Engl. 2015 Sep;54(9):1541–8.
• Tzoulis P, Evans R, et al. Multicentre study of investigation and management of inpatient hyponatraemia in the UK. Postgrad Med J. 2014 Dec;90(1070):694–8.
• Evans R, et al. Purple urinary bag syndrome. BMJ Case Rep. 2014. doi:10.1136/bcr-2014- 207483
• Evans R, et al. ANCA-associated vasculitis and pauci-immune glomerulonephritis in HIV disease. BMJ Case Rep. 2014. doi: 10.1136/bcr-2013-202423
• Evans R, Salama AD. Update on rituximab: an established treatment for all immune-mediated kidney diseases? Nephron Clin Pract. 2014;126(3):97–109.
• Evans R, et al. Tip variant focal segmental glomerulosclerosis associated with interferon-? treatment of multiple sclerosis. BMJ Case Rep. 2014. doi: 10.1136/bcr-2013-203077
• Evans R, et al. Thrombotic microangiopathy (TMA) in a patient treated with antiviral therapy for hepatitis C. BMJ Case Rep. 2014. doi: 10.1136/bcr-2013-203290
• Alifrangis C, Evans R, et al. An unusual gum lesion with a positive pregnancy test. BMJ. 2011;343:d5009.
• Evans RDR, et al. Spinal epidural abscess: a rare complication of olecranon bursitis. Orthop Rev. 2009 Jun 30;1(1):e1.
Book Chapters
• Renal Involvement in Primary Sjögren’s s Syndrome. Rhys Evans, Stephen Walsh. In ‘Oxford Textbook of Sjögren’s Syndrome. Ed. Price E, Tappuni A. Oxford University Press, 2021. ISBN 978-0-198-80668-4.
• Infectious Complications of Renal Transplantation. Rhys Evans, Sanjay Bhagani, Tanzina Haque, and Mark Haber. In 'Primer on Nephrology'. Ed. Harber M. Oxford, Springer, 2020. ISBN 978-3-030-76418-0.
• Establishing an AKI Service. Sarah Hildebrand, Rhys Evans, Ed Kingdon. In 'Primer on Nephrology'. Ed. Harber M. Oxford, Springer, 2020. ISBN 978-3-030-76418-0.
• Essential Practical Prescribing; Renal Chapter. Ed. Rhys Evans. Wiley-Blackwell, 2016. ISBN 978-1-118-83773-3
Research interests include the impact of salt and extracellular ions on immunity; immunological changes in tubular kidney diseases and hypertension; improving outcomes for kidney transplant recipients; high immune risk kidney transplantation; biomarkers of allograft injury; molecular transplant biopsy analysis; immunosuppression avoidance including cell therapy; improving global kidney care.